The Rapamycin Story: Promise vs Risks
Rapamycin, a drug discovered in the 1970s, has fascinated scientists for its potential to combat aging and disease. But despite the hype, its risks make it unsuitable for anti-aging today.
From Easter Island to the Lab
Unearthed in a soil sample from Easter Island, rapamycin began as a promising antifungal. However, its immunosuppressive effects sidelined it as a treatment for fungal infections.
In the 1990s, scientists discovered mTOR (mechanistic Target of Rapamycin), a master regulator of cell growth. Rapamycin’s ability to inhibit mTOR revolutionized transplant medicine, helping prevent organ rejection, and became a cornerstone for certain cancer therapies after its FDA approval in 1999.
The Anti-Aging Hype
Animal studies showed rapamycin could extend lifespan by inhibiting mTOR, sparking excitement for its anti-aging potential in humans.
Why It’s Not Ready for Anti-Aging
Despite its promise, rapamycin comes with significant risks:
- Weakened Immune System: Increased vulnerability to serious infections like pneumonia and cellulitis.
- Metabolic Issues: Elevated blood sugar and cholesterol levels.
A Conversation About Rapamycin
Recently, a friend asked if they should take rapamycin for better health. I explained its immunosuppressive nature and how it interferes with the immune system, making it risky for general use. “It’s not worth compromising your immunity”. I went on to explain other safer options. I also shared with him what I am doing for myself.
Lessons from Bryan Johnson
Tech entrepreneur Bryan Johnson, known for biohacking, recently stopped taking rapamycin after five years. He faced side effects such as skin infections, abnormal heart rate, and blood sugar spikes. New research suggesting rapamycin might accelerate aging in some areas solidified his decision. “The side effects don’t justify the risks,” he said.
The Verdict
Rapamycin holds promise for medical applications but isn’t safe for anti-aging. Until more research emerges, its risks outweigh the potential benefits.
Top 3 Anti-Aging Tips
- Eat Smart: Embrace a Mediterranean diet and try intermittent fasting for cellular rejuvenation.
- Move Your Body: Combine cardio, strength, and flexibility exercises to stay strong and youthful.
- Protect Your Skin and Sleep: Use sunscreen daily and prioritize quality sleep—it’s your natural repair system.
