Autologous Serum Therapy: A Breakthrough for Chronic Hives (Urticaria) Patients
When Chronic Hives Won’t Go Away, Autoimmunity May Be the Culprit
Living with chronic urticaria (hives) can feel like battling an invisible enemy. The persistent itching, unpredictable flare-ups, and red, swollen welts make daily life frustrating—and for many patients, standard antihistamines simply don’t work.
What if the real issue isn’t allergies but your own immune system attacking your skin?
Research suggests that up to 50% of chronic urticaria cases are caused by autoimmune activation of mast cells—where the immune system mistakenly triggers an allergic-like response without an external allergen.
Understanding Autoimmune Chronic Urticaria: Why Your Own Body Triggers Hives
Unlike traditional allergies, where the immune system overreacts to external triggers like pollen or food, autoimmune urticaria happens when the immune system misfires against its own body. This leads to constant histamine release from mast cells, causing chronic hives that appear without a known trigger.
There are two primary ways autoimmune urticaria occurs:
1️⃣ IgE Antibodies Reacting to Self-Antigens
Your body mistakenly produces IgE antibodies that react to an internal antigen—something your own body produces. This reaction triggers mast cells, leading to uncontrolled hives.
2️⃣ Autoantibodies Directly Stimulating Mast Cells
In this case, the immune system creates autoantibodies that directly activate mast cells, causing them to release histamine—even without an allergen present.
🛑 The result? Recurring hives that don’t respond to standard allergy medications.
The Science Behind Autologous Serum Therapy (AST)
Researchers discovered that autoimmune factors play a major role in chronic urticaria by conducting a self-skin test. In this test:
✅ A small amount of the patient’s own serum is injected under their skin
✅ If hives appear at the injection site, it confirms that something in the patient’s own blood is triggering mast cells
But what if, instead of just diagnosing the problem, we used the serum to train the immune system to stop overreacting?
That’s exactly how Autologous Serum Therapy (AST) works.
How AST Works: “Fighting Fire with Fire”
🔬 A sample of the patient’s own blood serum is extracted
💉 The serum is re-injected into the patient in a controlled manner
🛠️ This process gradually retrains the immune system, reducing overactive mast cell responses
Essentially, AST desensitizes the immune system—helping it recognize its own components as “safe” rather than as a threat.
Does Autologous Serum Therapy Work? The Results Are Promising!
Studies have shown encouraging results, particularly in patients whose chronic hives don’t respond to antihistamines.
📌 Key Findings from Research:
🔹 Patients typically begin seeing improvement after the 8th treatment session
🔹 Some achieved complete remission, with long-lasting relief
🔹 AST is especially useful for patients who want to avoid immunosuppressants or Biologic medications
🔹 The treatment is safe, well-tolerated, and offers long-term benefits
🔗 (Reference: Autologous Serum Therapy for Chronic Urticaria)
Why Choose The Allergy Immunology Clinic for Autologous Serum Therapy?
We have extensive experience diagnosing and treating complex cases of autoimmune chronic urticaria.
- Expert-Led Treatment – With specialization in Allergy & Immunology, the clinic has successfully treated many patients with personalized AST protocols.
- Proven Success Rates – We have seen significant symptom relief, reduced medication dependence, and even long-term remission in patients undergoing AST.
- Advanced Testing & Diagnostics – We don’t just rely on standard allergy tests. Our clinic goes deeper to uncover autoimmune triggers and craft targeted treatment plans.
- Safe & Monitored Therapy – AST requires precision and expertise, which is why our team ensures each patient receives optimal care throughout their treatment journey.
Are You a Candidate for Autologous Serum Therapy?
You may benefit from AST if you:
✅ Have chronic hives that don’t respond to antihistamines
✅ Prefer a natural, immune-based approach over long-term immunosuppressants
✅ Have tested negative for traditional allergies but still experience persistent hives
✅ Want a long-term solution rather than just masking symptoms
Take the First Step Toward Long-Term Relief
Chronic hives can feel frustrating and hopeless, but you don’t have to suffer forever. Autologous Serum Therapy offers a science-backed approach that targets the root cause—not just the symptoms.
At The Allergy Immunology Clinic, we’re committed to helping you break free from chronic urticaria and regain control over your skin—and your life.
📞 Book a consultation today to find out if Autologous Serum Therapy is right for you!
